Time course of l-epirenamine contents in a local anesthetics under various conditions.
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概要
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This study is on the effects of temperature, light and container type on the time course (1W, 2W, 3W, 1M, 2M, 3M) of the l-epirenamine reduction in local anesthetic agents. Lidocaine or prilocaine cartridge and lidocaine ampoule were prepared for this experiment. Assay of l-epirenamine was performed using electrochemical detector and high performance liquid chromatography. Loading conditions used in this experiment are as follows.<BR>1) The levels of l-epirenamine had remained unchanged for three months, when kept in a refrigerator or a room regulated at 5+1°C or 23°C. Preservation at 30°C in an incubator, however, showed a decrease of 18% in three month. There was no difference in reduction rate between two kinds of containers.<BR>2) The levels of l-epirenamine were remarkably decreased, when exposed to fluorescent or UV light in a room regulated at 23°C. Fluorescent light did not affect l-epirenamine levels in an ampoule but reduced those in a cartridge. UV light did not only decrease l-epirenamine levels in a cartridge but also in an ampoule.<BR>3) When an ampoule, which was mixed with minced plunger gum and resealed with gassing nitrogen, was exposed to fluorescent light, the reduction rate of the l-epirenamine levels were the maximal compared with all other loading conditions. These results show that the following : High temperature, fluorescent or UV light caused reduction of l-epirenamine levels. l-epirenamine in ampoule is more stable than in cartridge. Heavy metal contained in plunger gum may catalyze l-epirenamine oxidation by light. The storage of the local anesthetic agents should be done in low temperature and in dark.
- 日本歯科薬物療法学会の論文
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