Clinical evaluation of EB-382 (alminoprofen) on postexodontic inflammation. A double-blind comparative study.:A double-blind comparative study

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A multi-center double-blind comparative study was conducted in order to evaluate the effectiveness, safety and usefulness of EB-382 (600 mg/day) as preventive treatment for postexodontic inflammation of mandibular impacted wisdom tooth, with flurbiprofen (120 mg/day) as the reference drug. The results obtained were as follows: 1) The total number of patients were 324, 6 cases were excluded and the remaining 318 cases were evaluated, 162 cases were treated with EB-382 (EB) and 156 cases were treated with flurbiprofen (FP) . 2) Considering background parameters, there was no statistical significant difference between the two groups. 3) According to the doctor's judgement of the clinical efficacy, the rate of"excellent or good" was 75.5% with EB group and 75.2% with FP group. There was no significant difference between two groups. 4) Side effects were observed in 5 cases (3.1%) in EB group and 10 cases (6.4%) in FP group. 5) In the general utility rating, the rate of"extremely useful or useful"was 75.8% with EB group and 74.4% with FP group. There was no significant difference between two groups. The results indicate that administration of 600 mg/day EB-382 (in 3 divided dose) is safe and useful in the treatment of postexodontic inflammation.
日本歯科薬物療法学会の論文