Effects of prototype low viscid toothpaste containing cetylpyridinium chloride with interproximal brushes on gingivitis.
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概要
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There have been many applications of toothpastes and gargles containing antibiotic ingredients to periodontal treatment. Cetylpyridinium chloride (CPC) is one such anti-plaque ingredient with a content of 0.05%. This study evaluated the effects of interproximal brushes with a prototype low viscid toothpaste containing 0.05% of CPC on slight periodontitis and gingivitis at interproximal areas. The subjects were 60 patients who had not received general and/or local antibiotics or periodontal therapy for at least 3 months prior to this study. They had at least 1 interproximal area where interproximal brushes could be inserted on the maxillar or mandibular incisors to second premolars without prosthesis. Sampling sites were interproximal areas in each subject. The subjects in the experimental group were instructed as to brushing method and used interproximal brushes with the prototype low viscid toothpaste containing 0.05% of CPC. The other subjects in the placebo group used a prototype low viscid toothpaste without CPC and were given the same instructions as the experimental group of subjects. Mondified gingival index (MGI), modified plaque index (MPI), amount of gingival cervical fluid (GCF), probing depth (PD), clinical attachment level (CAL) and ratio of subgingival microflora were measured at baseline, and after 1 month and 2 months. The data from 23 patients in the experimental group and 25 patients in the placebo group were adopted in this study. MGI, MPI, GCF and PD in both groups showed a significant reduction with time. GCF and PD in the experimental group were significantly lower than those of the placebo group at 1 month. CAL in both groups did not change at any period. Ratio of cocci increased with time in both groups, accordingly rods decreased with time. Spirochetes and motile rods were scarcely detected at every period. These results suggested that the use of low viscid toothpaste containing 0.05% of cetypyridinium chloride with interproximal brushes could quickly improve gingivitis.
- 日本歯科薬物療法学会の論文
日本歯科薬物療法学会 | 論文
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