Study on G-CSF in Saliva Regarding the Defense Mechanism of Oral Infections. Part 1. Concentration of G-CSF in Saliva.:—Part 1 Concentration of G-CSF in Saliva—

概要

論文の詳細を見る
In seven healthy volunteers, blood and saliva concentration of physiological granulocyte colony-stimulating factor (G-CSF) were measured in order to examine the local effects on the intraoral cavity. Furthermore, the pharmacokinetics of a G-CSF agent (lenograstim) was studied. The results were as follows : 1) The blood concentration of physiological G-CSF was 9.5±1.8pg/ml (n=7), and the saliva concentration was 21.2±11.9pg/ml (n=7) . That is to say, the saliva concentration of physiological G-CSF had about a two-fold increase as compared with the blood concentration. This suggests that G-CSF in saliva directly augments the function of salivary polymorphonuclear leukocytes (S-PMN) . 2) Transmigration of G-CSF agent into saliva is less than 10% of that into blood.
日本歯科薬物療法学会の論文