Adverse Reaction of Local Tissue of Rabbits to Sodium Hypochlorite.

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Sodium hypochlorite (NaOCl) is widely known to cause severe local irritation in a high concentration of 10 %, which is generally used for root canal cleaning in endodontic treatment. The cleaning effect has already been investigated in less than 10 % in order to find the minimal effective concentration. Little work, however, has been done to clarify its concentration-irritation relationship. In this study the solutions of serial dilutions in 2<SUP>-n</SUP> (n=0-8) of 10 % NaOCl and isotonic sodium chloride solution, a control, were injected intracutaneously into the skin of 3 rabbits, which were sacrificed 30 minutes, 3 days or 1 week after the injection. The sites of the injection and surrounding tissue were examined by the usual histopathological method. The changes in the structure caused by NaOCI were summarized as follows : Bleeding was found in all cases with concentration over 2.5 % throughout the observation period, and the most remarkable in the 30-minute case. Necrosis was caused in all cases over 5 % throughout the period, and in cases over 0.16 %, a degenerated tissue with hypochromatism, regarded as necrobiotic layer, appeared contiguous to the necrotic area in the 1-week case. Adjacent to the area of necrotic and necrobiotic, granulation tissue developed in cases over 0.63 %. Hyperaemia and inflammatory cell infiltration were observed in all cases over 0.04 % throughout the period and the latter was the most remarkable in the 3-day case. The findings related to inflammation were fewer as the concentration was lower, especially in cases less than 2.5%.<BR>From the above it was confirmed that the severe adverse reaction of the local tissue to the 10 % NaOCl was considerably reduced by decreasing its concentration.
日本歯科薬物療法学会の論文

Adverse Reaction of Local Tissue of Rabbits to Sodium Hypochlorite.

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日本歯科薬物療法学会 | 論文

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