Effect of antibiotics on macrophage phagocytosis.

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The effect of 7 antibiotics, ampicillin (ABPC), cefotiam (CTM), cephalexin (CEX), tetracycline (TC), amikacin (AMK), clindamycin (CLDM) and bleomycin (BLM), on phagocytosis of rat peritoneal macrophages in vitro were studied and compared with that of controls. The following results were obtained. 1. All antibiotics except ABPC showed dose-dependent decrease of both phagocytosis ratio and index at doses of 10-1000ug/ml or more. 2. CTM, CEX, TC, AMK and CLDM showed significant decrease of phagocytosis ratio (p<0.001) at the dose of 100-1000ug/ml or more. 3. Significant decrease of phagocytosis index were shown in CTM, CEX and CLDM (p< 0.01: 1000, ug/ml), TC (p<0.001: 1000ug/ml) and AMK (p<0.01: 100, ug/ml and p<0.001: 1000ug/ml) . 4. BLM showed significant decrease of phagocytosis ratio (p<0.001: 10-1000 tg/ml) and phagocytosis index (p <0.01: 10ug/ml, p <0.001: 100-100ug/ml) . 5. ABPC slightly showed dose-dependent increase of both phagocytosis ratio and index, but was not significantly different from those of controls. 6. The pH of all antibiotics dissolved in Dulbecco's Modified Eagle Medium varied only between 6.8 and 7.4 with all doses.
日本歯科薬物療法学会の論文