Penetration of Cefpodoxime proxetil (CPDX-PR) into tooth extraction wound and oral tissues.
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The concentration of CPDX in serum, tooth extraction wound and oral tissues after single administration with CPDX-PR 100 mg or 200 mg were determined, and the result was obtained as follows:<BR>1. CPDX-PR 200 mg was administered to 59 patients to examine serum concentration of CPDX. The serum level as CPDX ranged from 0.19 to 5.87 μg/ml, mean±S. D. value was 2.37±1.23 μg/ml. when the serum level was set at MICs of Oral Streptococci (0.78μg/ml) as a target level, 89.8 % of patients showed levels exceeding the target level.<BR>2. To examine an effusion of tooth extraction wound of CPDX, CPDX-PR 200 mg was administered to 207 patients. After 135-300 minutes, 82.8% of patients showed effusion concentrations higher than the target level (0.78μg/ml) .<BR>3. After oral administration of CPDX-PR 200 mg, the peak level of CPDX in gingiva, alveolar bone, dental sac and cyst wall were 2.20μg/g, 1.07μg/g, 2.04μg/g, 1.77μg/g, respectively, and its mean±S.D. value were 1.17+0.43μg/g (21 samples), 0.57+0.24μg/g (15 samples), 0.97±0.54 μg/g (13 samples), 0.96±0.62μg/g (12 samples), respectively.<BR>4. The transfer ratio of effusion of tooth extraction wound levels to serum level was 66.6%, and its ratio of gingiva, cyst wall, dental sac and alveolar bone levels were 47.3%, 37.6%, 37.5%, 17.7%, respectively.<BR>From the above results, the concentration of CPDX in serum, tooth extraction wound was high, and good penetration into oral tissues was obtained.
- 日本歯科薬物療法学会の論文
日本歯科薬物療法学会 | 論文
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