Clinical study on adjuvant immuno-chemotherapy for carcinomas of salivary gland. Cases followed-up for more than 10 years.:—Cases followed-up for more than 10 years—

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Twenty-four patients with salivary gland carcinomas underwent surgery with and without irradiation, following adjuvant immuno-chemotherapy and followed-up for at least 10 years. There are many patients with major salivary gland tumors and adenocystic carcinomas in stage II and IV. The adjuvant immuno-chemotherapy consisted of 5-FU analogue and OK-432 and was performed for 2 years after loco-regional treatment. The survival rates and the incidences of primary recurrence, cervical node metastases, and distant metastases and the mean times of relapses since initial treatments were examined.<BR>The incidences of primary recurrence, cervical lymph node metastases, and distant metastases are 20.8%, 16.7% and 33.3%, respectively, and the mean times of these relapses are 4y9m, 1y7m and 4y7m, respectively. As to development of distant metastases among the loco-regionally controlled cases, the occurrence rate is 23.8% and the mean time of relapse is 5y8m.<BR>Five- and ten-year survival rates by Kaplan-Meier methods are 83.3% and 70.8%, respectively. Among the loco-regionally controlled cases, five- and ten-year survival rates are 90.5% and 81.0%, respectively.
一般社団法人日本口腔腫瘍学会の論文