Two cases of oral cancer responding to chemotherapy with UFT.

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Two patients with oral cavity malignancies, which showed excellent responses to chemotherapy with UFT, are reported. One patient was a 71-year-old female who had undergone radical surgical resection of cancer of the tongue (T2N0M0) . However, after 4 years and 7 months the malignancy recurred at the resected margin on the floor of the mouth. The patient refused a second radical resection, so UFT was p.o, administered at a dose of 600 mg/day. The tumor showed a tendency to shrink beginning from the 2nd week of UFT therapy, and by the 4th week the tumor had been clinically disappeared. Histopathological examination also indicated a complete response (CR) . The second patient was an 83-year-old male who had a mandibular gum carcinoma (T1N0M0) with a complication of asthma. Therefore, in consideration of the patient's quality of life, a combination of UFT at 600 mg/day and ubenimex (Bestatin) at 30 mg/day was p.o. administered. The tumor began to shrink from about the 3rd month of treatment, and it had clinically disappeared by the 6th month. The histopathological findings also indicated CR. Both of these patients are disease-free, and they are still under observation.
一般社団法人日本口腔腫瘍学会の論文