Significance of combined neoadjuvant chemotherapy on oral cancer. 1. The clinical effects of cisplatin-vinblastine-peplomycin(CVP) combination chemotherapy included in two route administration and its prognostic significance.:1. The clinical effects of ci

概要

論文の詳細を見る
The therapeutic effects of neo-adjuvant chemotherapy administered by two route infusion of cisplatin and its antidote, sodium thiosulfate, and intravenous infusion of vinblastine and peplomycin were studied on 35 patients with previously untreated squamous cell carcinoma of the oral cavity, maxillary sinus, or oropharynx. The overall response rate to chemotherapy was 91.4%, and complete response rate was 57.1%. When the patients who died of a disease other than tumor were excluded, the cumulative 5-year survival rate was 100% in CR and 87.5% in PR plus NC. This chemotherapy could be carried out in a shorter time period because of the appropriate supporting therapy. Twelve out of 20 CR patients underwent conservative surgery, and they are all free from tumor and have good oral function. These data showed that this chemotherapy may be more effective for treatment of head and neck cancer. The results are preliminary, and additional studies using more patients are needed.
一般社団法人日本口腔腫瘍学会の論文