Experimental epithelial dysplasia produced by heterocyclic amine (Trp-P-2, Gly-P-1) treatment and injury.
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概要
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The purpose of this study was to investigate histologically the changes of epithelial cells in the tongue which was injured and pained by carcinogen Trp-P-2 (3-amino-1-methyl-5Hpyrido [4, 3-b] indole) or GIu-P-1 (2-amino-6-methyldipyrido [1, 2-a: 3', 2'-d] imidazole) . Hamsters were divided into 10 groups (Groups A-J) . In Groups A and F, the tip of the tongue was painted three times a week with distilled water for 16 weeks. In Groups B, C, G and H, the tip of the tongue was painted three times a week with a 1 % Trp-P-2 solution for 16 weeks. In Groups D, E, I and J, the wound was painted three times a week with with a 1 % GIu-P-1 solution for 16 weeks. At the end of 16 weeks, in Groups A, B, C, D and E, the tip of the tongue was excised with scissors, while in Groups F, G, H, I and J, the tip was not excised. Then, in Groups A and F, the tongue was painted daily with distilled water until the animals were sacrificed. In Groups B and G, the tongue was painted daily with Trp-P-2 solution until the animals were sacrificed. In Groups D and I, the tongue was painted daily with GIu-P-1 solution until the animals were sacrificed. In Groups C, E, H and J, the animals received no treatment until they were sacrificed. Animals of all groups were sacrificed 15 days after the excision or after the end of 16 weeks. The tongue was examined histologically.<BR>1) Group A. The tongues of all animal showed only hyperkeratosis.<BR>2) Groups B and E. One animal in Group B and two in Group E showed changes of slight to moderate lingual epithelial dysplasia. These changes included disorientation of cells. cellular and nuclear pleomorphisms, nuclear hyperchromatism, increased number of mitotic figures, abnormal keratinization, and elongation of epithelial projection. The remaining animals had tongues similar to those of Group A.<BR>3) Groups F, G, H, I and J. The tongues of all animals were normal.<BR>The results of this study indicated that epithelial dysplasia of the hamster tongue was produced by both excision and heterocyclic amine treatment (Trp P-2, GIu-P-1) .
- 一般社団法人 日本口腔腫瘍学会の論文
一般社団法人 日本口腔腫瘍学会 | 論文
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