An experimental study of electrochemotherapy for a rat tongue carcinoma model.
スポンサーリンク
概要
- 論文の詳細を見る
Electrochemotherapy (ECT) is a new technique that enhances the antitumor effect of various anticancer agents by delivering high-voltage electrical impulses to the tumor. In the present study, ECT was used in the treatment of oral cancer using SCC158 cell, a rat squamous cell carcinoma, which was transplanted into the tongue. These tumors were subjected to high-voltage electrical impulses (1200V/cm, 0.1msec, 8 pulses) 30 minutes after the injection of bleomycin. The antitumor effect of ECT on these tumors was then evaluated, as were histological changes in the damaged tumor, and healing of the surrounding damaged tissue. In a further experiment, to determine the optimum voltage of electrical impulse histologically, these tumors received various electrical pulses (125-1200V/cm, 0.1msec, 8 pulses) in ECT.<BR>As a result, the tongue tumors were no longer visible from the 3rd day after ECT, and histological examination revealed complete regression. The healing following ECT proceeded in an almost uneventful manner, but the normal tissue within the electrical field was necrotic. In addition, the antitumor effect of ECT appeared most strongly when the voltage was more than 1000V/cm ; however, the surrounding normal tissue within the electrical field was seriously damaged.<BR>In conclusion, ECT was shown to be an efficient therapy for treating tumors of the tongue, and it is expected to be applied to human oral cancer. It is hoped that problems related to damage to normal tissue and the inducement of metastasis will soon be resolved as a result of future investigations.
- 一般社団法人 日本口腔腫瘍学会の論文
一般社団法人 日本口腔腫瘍学会 | 論文
- 進行口腔癌に対する逆行性超選択的動注化学療法, 放射線同時併用療法後の救済手術
- TS-1による化学療法と温熱放射線療法が著効した後発頸部リンパ節転移の1例
- 手術シミュレーションに基づく腫瘍分割摘出により顎骨を保存した得た下顎骨骨形成線維腫の1例
- 口腔癌における化学・放射線療法後の再発・二次再建に関する外科療法の検討
- 下顎骨再建 : 血管柄付遊離骨移植と遊離軟部組織移植の比較