Evaluation of Argyrophilic Nucleolar Oganizer Regions(AgNORs) and its clinical application to tongue squamous cell carcinomas.
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Using a silver staining technique, argyrophilic nucleolar organizer regions (AgNORs) were studied using biopsy specimens taken from 62 tongue squamous cell carcinomas (SCC), and the relation of the results of AgNORs to the clinicopathological findings, labeling indices of proliferating cell nuclear antigen (PCNA LI), and the outcome of the disease were investigated. The mean numbers of AgNORs per cell were 1.6±0.2 (n=10) in control squamous epithelia and 3.6±1.1 (n=62) in the tongue SCCs, respectively, and a significant difference was found between the two groups (p<0.0001) . As for the clinicopathological findings, the mean numbers of AgNORs in the progressive cases (T3-T4, N1-N2, Stage III-IV) were statistically higher than those in earlier tumors (T1-T2, N0, Stage I -II) . A similar higher value of the AgNOR count was present in the histological grade III, diffuse invasion and severe atypia tumor. There was also a direct significant correlation between the AgNOR counts and the labeling indices of PCNA (r=0.520, p<0.0001) . As for the outcome of the disease, the mean numbers of AgNORs were higher in the group with local recurrence or with lymph-node metastasis. There was a lower rate of 5-year survival (63.5%) in the high value group of AgNORs compared with that (86.0%) of the low value group, with a significant difference between the two groups (log rank: p=0.04) .<BR>The results suggested that the AgNOR count reflect the degree of malignancy and cellular proliferation in tongue SCCs.
- 一般社団法人 日本口腔腫瘍学会の論文
一般社団法人 日本口腔腫瘍学会 | 論文
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