An experimental study on the induction of cartilage and bone formation by cells from rat pulp, periodontal ligament and bone marrow.

概要

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Both osteogenic and inductive capability <I>in vitro</I> by cells from muscle, subcutaneous connective tissue, bone marrow, periodontal ligament and the dental pulp of rats on either mineralized or demineralized bone and dentin matrices were investigated.<BR>Specimens were examined 28 days after culture using light microscopy and the proportion of new hard tissues were also analysed.Induction of cartilage occurred in muscle but not in the others, and new bone-like tissue formation occurred mostly in the dental pulp followed by bone marrow and the periodontal ligament, but neither in both skin nor muscle.Calcification occurred mostly in the dental pulp followed by the periodontal ligament, bone marrow, muscle and subcutaneous connective tissue.<BR>These results suggest that osteogenic cells such as the pulp, periodontal ligament and bone marrow cannot easily respond to inductive stimuli such as bone morphogenetic protein.
歯科基礎医学会の論文