Temperature-Dependent Cellular Lysis in Streptococcus mutans HS 6

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Temperature dependent cell-lysis was studied in Streptococcus mutans strain HS 6 as exposed to a variety of cultural conditions. Cell-lysis was observed in media supplemented with glucose, sucrose and maltose but it failed to occur when none of the sugars except fructose was added to the media. The cell-lysis of S. mutans in glucose-enriched media could be influenced in a variety of manner so that addition of agents that interfere with glycolytic pathway or with cell wall synthesis could act to suppress the cell-lysis, and those agents that interfere with DNA and RNA synthesis acted to accerelate the cell-lysis, whereas addititon of inhibitors of protein synthesis somewhat interfered with the cell-lysis of this organism. When N-acetyl-D-glucosamine was added to the culture media instead of glucose, the cell-lysis was seen at the concentration of the former as small as 1/25 th of the latter. With use of the above media containing N-acetyl-D-glucosamine, the role of saturated fatty acids in suppressing the cell-lysis became distinct. These evidences seem to show that the strain HS 6 of S. mutans is very susceptible to high temperatures at the time of its synthesis of saturated fatty acids, resulting weakness of cell membrane, which can be easily destroyed by smaller shock.
歯科基礎医学会の論文