Efficacy of Immunotherapy with Japanese Cedar Pollen Extract for Cypress Pollinosis

概要

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Background: A high incidence of Japanese cedar pollinosis has been reported in Japan. Most of these patients are also known to suffer from cypress pollinosis. This is related to the similarity of the sequences in Cry j 1 of Japanese cedar pollen and Cha o 1 of cypress pollen. The purpose of this study was to determine the efficacy of Immunotherapy with Japanese cedar pollen extract against cypress pollinosis.Methods: We posted questionnaire to patients with Japanese cedar pollinosis that had been receiving Immunotherapy for more than three years (IT-group), and received anonymous responses from 16 of these patients. The same questionnaire was also sent to patients who were on medication (M-group). The patients were selected from those who also had cypress pollinosis.Results: The IT-group showed statistically significantly better scores on the visual analog scale (VAS) in sneezing, watery rhinorrhea and eye itching during the cedar pollen season than the M-group. However, no differences were observed between the two groups during the cypress pollen season.Conclusion: Immunotherapy with Japanese cedar pollen is not effective for cypress pollinosis.
日本鼻科学会の論文