Cell Dynamics of Dividing Cells in the Olfactory Bulb of Guinea Pigs.
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Neural and glial cells in the olfactory bulb of rats were reported to regenerate even after birth. We studied cell division dynamics the guinea pig olfactory bulb using immunohistochemical double staining. Anti-bromodeoxyuridine (BrdU) antibody for detecting dividing cells, anti-calbindin antibody, antiprotein gene product antibody for neural cells, and anti S-100 antibody for glial cells were used immunohistochemical staining.At 1 hour after BrdU injection, many BrdU-labeled cells were present in the subventricular zone. BrdU-labeled cells migrated from the subventricular zone to the subependymal zone of the olfactory bulb through rostal migratory pathway within 5 days. Labeled cells then moved peripherally from the bulb zone differentiated neural cells and filial cells in some layers.
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