Eotaxin expression on nasal polyp tissue-derived fibroblasts.

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概要

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• Eosinophil infiltration of tissue is a hallmark of nasal polyps in both atopic and nonatopic patients. Structural cells like airway fibroblasts are a rich source of cytokines and inflammatory mediators. To verify whether nasal fibroblasts play a role in eosinophilic infiltration, we investigated the release of eotaxin from nasal polyp fibroblasts when stimulated with lipopolysaccharide (LPS), interleukin-1β and tumor necrosis factor-α. We demonstrated that LPS, proinflammatory cytokines (IL-1β and TNF-α) could induce the gene expression and production of eotaxin in nasal polyp fibroblasts. These findings suggest that nasal polyp fibroblasts may play an important role in the recruitment of eosinophils through the release of eotaxin.

• 日本鼻科学会の論文

日本鼻科学会 | 論文

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