Treatment of maxillary sinusitis in children with nasal allergy.

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The clinical effects of Clarithromycin (CAM), S-carboxymethylcysteine (S-CMC) and anti-allergy agents were investigated in children with maxillary sinusitis and nasal allergies. The subjects were 95 children, 14 years or younger. The maxillary sinusitis was diagnosed by X-ray examinations. The pataients were classified into two treatment groups. Patients in group A received both 5-7mg/kg per day of CAM and 30mg/kg per day of S-CMC for 12 weeks, and those in group B received only 30mg/kg per day of S-CMC for 12 weeks. All patients in the study were also treated with anti-allergy agents. Moreover, the nasal treatment were given once a week locally.On the fourth month after beginning treatment, X-ray examinations of the maxillary sinus showed 63.9% and 62.7% of cure rates in group A and B, respectively. There was no significant difference in cure rates between group A and B. These results suggest that the efficacy of treatment of maxillary sinusitis in children with nasal allergy is related to a regimen of S-CMC and anti-allergy agents and that CAM provides no added benefit to S-CMC and anti-allergy agents. The study also found an age-related decline in cure rates in goup A. This suggests that there may be pathological changes in their sinusitis as patients grow older.
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