Seven cases with malignant melanoma of the nasal cavity and paranasal sinus.

概要

論文の詳細を見る
Seven patients with malignant melanoma of the nasal cavity and paranasal sinus were treated at Yokohama city University from August 1991 to July 1998. The sex distribution was 3 males and 4 famales, and their ages ranged from 40 to 74 years (mean: 57 years). The chief complaints were epistaxis and nasal obstruction. Generally, nasal examinations revealed black masses, and whitish or grayish nasal polyp-like masses were also observed in some cases. Histopathologicallt, the diagnosis of this tumor is very difficult, therefore immunohistochemical examination is useful for difinitive diagnosis.Theatment modalities for this tumor consisted of various combination therapies in-cluding surgery, radiotherapy, chemotherapy and immunotherapy. Combination chemotherapy consisting of dimethltriazeno imidazole carboxamide (DTIC, Dacarbazine), amino methyl pyrimidinyl chlorethy nitrosourea hydrochloride (AGNU), vincristine (VCR), and cisplatin (CDDP) were administered, whereas chemotherapy was not effective for these patients. Surgical treatment as an initial therapy was performed in 6 patients. In three of these, melanoma cells were located multifocally in both the nasal cavity and paranasal sinuses. On the basis of the characteristics, the surgical margin should be carefully determined for this tumor.
日本鼻科学会の論文