Evaluation of initial treatment with IPD on Japanese cedar pollinosis. Trial at the same time in three different regional facilities.:Trial at the same time in three different regional facilities
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概要
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Initial treatment for Japanese cedar pollinosis has come into wide use as their effectiveness have been reported. However, the most appropriate starting time of administration and the best medicine have not been established. The effect of IPD for the initial treatment was examined in three regional facilities-Fukui, Kyoto and Osaka-which have different pollen counts. Tranilast was used in comparison. The correlation between clinical efficacy and chemical mediator in nasal lavage fluid was investigated. The amount of cedar pollen in 1997 was as follows-Fukui, 4835/cm2; Kyoto, 1285/cm2; Osaka, 1515/cm2. The comparison of inhibitory effectiveness of symptom between IPD and Tranilast was not significant after the first peak of cedar pollen dispersion. However after the second peak of cedar pollen dispersion, IPD significantly inhibited symptoms. IPD's inhibitory effect showed a fine record that rated excellent at 48.1% and good at 74.1% after the first peak. On the other hand, the comparison of results between facilities was not significant. The change of eosinophil cationic protein (ECP) concentrations in nasal lavage fluid was correlated with clinical effect. IPD significantly decreased the secretion of ECP in comparison to Tranilast. However, no correlation was found between the change in histamine concentrations and clinical effect. These results suggest that ECP concentrations in nasal lavage fluid is an effective index of objective evaluation at the initial treatment for Japanese cedar pollinosis. In addition, the changes in ECP concentrations in nasal lavage fluid can expect the efficacy of an initial treatment and serve as a good index for selecting a suitable medicine.
- 日本鼻科学会の論文
日本鼻科学会 | 論文
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