Malignant fibrous histiocytoma of the maxillary sinus: a case report.

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Although malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of adulthood, it is a rare tumor of the head and neck. We encountered a case of MFH arising from the maxillary sinus, and report on its diagnosis and treatment along with a review of pertinent papers. The patient was a 42-year-old male who presented with a four-month history of numbness in the left cheek. CT and MRI showed a left maxillary lesion with bone destruction of the anterior wall. Biopsy revealed MFH of the storiform-pleomorphic type. Immunohistochemically, the tumor stained positive for vimentin and α-1-antitrypsin, but negative for keratin, EMA, and p53. The patient was treated by preoperative Linac X-ray irradiation combined with intra-arterial infusion of Carboplatin and 5-FU followed by total maxillectomy. Pathological evaluation of the resected tumor showed a favorable response with extensive necrosis.
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