Branching of N- and O-Glycans: Biosynthetic Controls and Functions.:Biosynthetic Controls and Functions

概要

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Cell surface complex carbohydrates have been implicated in many physiological and pathological phenomena. The branching patterns of the N- and O-glycans are believed to be important in many of these processes. N-Glycan branching is controlled by a series of N-acetylglucosaminyltransferases (GnT) which initiate the antennae attached to the N-glycan core. GnT I, the enzyme which attaches GlcNAc in β1, 2 linkage to the Manα1-3Manβ1-4arm of the core, must act before any branching can occur. The genes for GnT I and for several other glycosyltransferases have recently been cloned in several laboratories. This work is providing evidence on how the tissue-specific and time-dependent expression of cell surface carbohydrates may be controlled.
FCCA(Forum: Carbohydrates Coming of Age)の論文