Studies on a Food Poisoning Caused by the Roe of "Nagazuka" (Stichaeus grigorjewi HERZENSTEIN):III. Antigenicity of the Toxic Substance and Experimental Therapy-test for Mice Inoculated with the Toxic Substance

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In this study, the antigenicity of the toxic substance and therapeutic effects of various medicines on mice inoculated with the toxic substance were experimentally observed. Results obtained were summarized as follows; 1) It was reaffirmed that the water-soluble toxic substance is not contained in the roe of "Nagazuka" (shown on Fig. 1). 2) When fresh roe of "Nagazuka" was emulsified with 0.8% NaCl solution, the volumn of which was 4 times the one of the roe and was stored at 25°C, 10°C and 0-3°C, toxicity of water-soluble toxic substance appeared within 7hr at 25°C, after 4-5 days at 10°C and after 6 days at 0-3°C. It was, however, believed that these are likely to be caused by the degredation of freshness of the sample because these toxicities were not markedly similar to the original toxicity of the roe of "Nagazuka" (shown on Table 1 and 2). 3) The toxicity of the fresh roe of "Nagazuka" was not affected by the digestion with trypsin (shown on Fig. 2). 4) This toxic substance lacked antigenicity as complete antigen. According to the authors' viewpoint this substance is hapten, namely, simple hapten or complex hapten. But this hypothesis must be confirmed by further study (shown on Table 3-5). 5) Experimental therapy-test on mice inoculated with the toxic substance, using various medicines, was conducted but satisfactory results were not obtained (shown on Table 6).
公益社団法人日本食品衛生学会の論文