Survey of Anti-Mutagens in Foods Based on the Inhibition of SOS Responses

概要

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In order to detect anti-mutagens, foods investigated in the total diet study were surveyed with the umu test, which is a new system to detect environmental mutagens. Its principle is to detect the induction of SOS responses which are involved in the formation of mutation. SOS responses were induced with various mutagens, and the suppressive effect of food was studied.Vegetables and fruits showed suppression when SOS responses were induced by activated Trp-P-1. These foods did not show suppression when SOS responses were induced by UV irradiation, suggesting that inactivation of Trp-P-1 may cause the suppression. Coffee suppressed the induction of SOS responses not only by activated Trp-P-1 but also by UV or AF-2. The suppressive effect of coffee seems to be due to an effect other than the inactivation of mutagens.
公益社団法人日本食品衛生学会の論文