Studies on the Teratogenicity of Food Additives (4):Effects of Food Dye Red No. 104 (Phloxine) on the Pre- and Postnatal Development in Rats in Relation to Fetal Distribution

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Food dye Red No. 104 (phloxine) was administered to Wistar pregnant rats at levels of 0, 0.3, 1, and 3% in diet during pregnancy and teratogenic effects, and fetal and maternal organ distributions were examined.A suppression in maternal body weight gain and growth retardation in fetuses were observed in the highest dose group. No evidences of increase in fetal death and malformation were obtained in all groups. The postnatal development was maintained well without any adverse effects. However, all newborn from 4 out of 5 dams in 3% group were killed by cannibalism within 2 days after birth.The concentrations of phloxine in fetus organs were lower than those in the placenta and in the most of maternal organs. The embryonic toxicity was discussed in relation to fetal distribution of the dye.
公益社団法人日本食品衛生学会の論文