Antimicrobial Action of Peracetic Acid (2):Action of Peracetic Acid on Nucleic Acid (DNA) and Its Bases
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概要
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Peracetic acid acted on purine and pyrimidine bases, and these nucleosides. This action was markedly affected by pH in reaction media. Peracetic acid also acted on deoxyribonucleic acid (DNA). It has been revealed through the base analysis of DNA that one of the actions of peracetic acid on DNA is the action on the base constituents. Their decomposition by peracetic acid was stronger under acidic condition than under neutral or alkaline condition. In addition, the decrease of the viscosity of DNA solution was observed. It was suggested that the decrease may be due to degradation of DNA molecule such as the hydrolysis of internucleotidic linkages, etc.
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