Studies on the Teratogenicity of Food Additives (3):Teratogenic Effect of Dietary Salicylic Acid in Rats

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Salicylic acid was administered to pregnant rats at levels of 0.06, 0.1, 0.2 and 0.4% in diet from the 8th to 14th day of gestation, and its teratogenic effects were examined.<BR>A temporal body weight loss with toxic symptoms such as salivation, piloerection following the administration was observed in 0.4% group, and also high mortality and growth retardation in fetuses were noticed. Not any toxic signs were observed in other three lower dose groups, but a significant growth retardation was noticed in fetuses of 0.2% group. Some kinds of anomalies with considerably high frequency were occurred in both groups of 0.4 and 0.2%, but not in the low dose groups below 0.1%.<BR>In the postnatal observation, in 0.4% group only 6 newborn were obtained alive from one dam and all died within 1 day after birth. Among low dose groups below 0.2%, no marked difference in litter size and in weaning rate at 8 weeks after birth and no evidence of growth retardation were obtained. In the postmortem examination, neither external nor internal organ anomalies were found in all groups, but minor changes in cervical bone occurred in some pups of 0.2% group.<BR>These findings support a view that salicylic acid acts as embryotoxic and teratogenic in rat, even after administration by dietary route as well as forced oral administration.
公益社団法人日本食品衛生学会の論文