Contribution of Neutrophils to Aspergillus Infection.
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概要
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Neutrophil disfunction, caused by a decreased production of effective radical oxygen species by myeloperoxidase (MPO) and NADPH oxidase within the neutrophil, may result in susceptibility to opportunistic fungal infections. <I>In vitro</I>, MPO produces OC1, which kills bacteria and viruses. In the case of MPO deficiency, susceptibility to <I>Candida albicans</I> infection was observed. Furthermore, it was demonstrated that MPO knockout mice were primarily susceptible to <I>C. albicans</I> infection. With regards to NADPH oxidase deficiency, such a patient was found to have severe chronic granulomatous disease (CGD) due to <I>Aspergillus</I> infection. This deficiency may have resulted from a gene mutation and/or abnormality of the NADH oxidase components, particularly cytochrome b<SUB>558</SUB> (gp 91 <SUP>phox</SUP> and p 22 <SUP>phox</SUP>) in membrane and cytosol factors p 47 <SUP>phox</SUP>, p 67 <SUP>phox</SUP>, p 40<SUP>phox</SUP> and others in neutrophil. Thus, irregular regulation of transcription factors for gene expression of phox molecules and MPO permits susceptibility to <I>Aspergillus</I> and <I>Candida</I> infections.
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