Culture Filtrate of Aspergillus fumigatus and its Cytotoxic Activity Against Leukocytes.
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概要
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Aspergillosis has become the biggest cause of death among mycoses in Japan. The main causative agent is <I>Aspergillus fumigatus</I> and its virulence factors have been variously investigated, yet much remains to be clarified.<BR>We recently found that the culture filtrate of <I>A. fumigatus</I> has potent anti-leukocyte activity. It seriously damages macrophages and hampers the function of polymorphonuclear neutrophils. The filtrate is also active <I>in vivo</I> : when injected intraperitoneally, the culture filtrate lowered the survival of mice infected with <I>A. fumigatus</I>. This activity becomes overt within 24 hours of culture of the fungus. Although the mechanism of pathogenicity of <I>A. fumigatus</I> is believed to be somewhat complex, we suggest the activities shown in the culture filtrate may play a crucial role in the development of the infection.
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