Genome Information and the Repetitive Sequences in Candida albicans.

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In the yeast Candida albicans karyotype variation among strains such as change in specific chromosome size or in the number of chromosomes is frequently observed. We have found one repetitive sequence (RPS) which might be involved in karyotypic variation. Sequences of several RPSs showed that the variability among them was derived from the variable number of repetitions of the inner repeating unit, alt. In investigating the RPS region, we found that another element distinguishable from RPSs neighbors the RPS region on a respective chromosome. Recently a new sequence, HOK, was isolated and its base sequence was determined.Homology search of HOK showed a significant level of homology with a portion of the isocitrate dehydrogenase gene of Saccharomyces cerevisiae. We also detected that a part of HOK was transcribed by Northern analysis, though it had no corresponding size of an open reading frame in HOK. It is therefore assumed that the HOK transcript act as an RNA molecule.Now we can browse and get a variety of information about Candida albicans from the Internet, including a restriction map using an Sfi I, alignment of fosmid clones, a list of cloned genes, and some molecular biological methods. We can also append a mailing list focusing on Candida and Candida research. Sharing the information will make Candida research easier and more familiar to many researcher.
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