Suppressive Effects of Aspergillus Products on Host Defence Mechanisms.
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概要
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Aspergillus species, especially A. fumigatus is known to cause a wide spectrum of illness, however, the pathogenic mechanisms are still poorly understood. We investigated the effects of A. fumigatus mycotoxins (gliotoxin, fumagillin, helvolic acid, and Asp-hemolysin) on human phagocytic functions in vitro, and demonstrated that these mycotoxins interfered with inhibition of conidia germination by AM, migration of PMN, superoxide anion release from PMN and hyphal damage by PMN in vitro. These suppressive effects of A. fumigatus mycotoxins were dose dependent, with relative potencies of gliotoxin>>fumagillin≥helvolic acid>>Asp-hemolysin. A. fumigatus mycotoxins, especially gliotoxin may play important roles in the pathogenesis of pulmonary infection by A. fumigatus, presumably via suppression of the phagocytic functions, since these functions are the central parts of the host defence network against Aspergillus species.
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