Effects of Itraconazole on Cell Membrane of Murine Macrophages.
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概要
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Itraconazole, an antifungal azole, was tested for its effects on the cell membrane of murine macrophages. When macrophages were cultured in the medium with less than 8.0μg/ml of ITCZ for 20hr, they were scarcely stained by trypan blue, which means that ITCZ by itself did not cause a significant damage to the cell membrane. However, the ITCZ-pretreated macrophages became stainable by trypan blue after treatment with sodium deoxycholate (DOC) solution (0.0375%), which was not toxic to non-treated macrophages. More than 0.5μg/ml of ITCZ made the macrophages susceptible to DOC treatment with 2hr-culture. Augmented DOC susceptibility of macrophages was observed by hydroxy-ITCZ as well as ITCZ, but not by the other azoleas. When macrophages were cultured in the presence of the combination of ITCZ and FK-23, an enteroccocal preparation with macrophage-stimulating activity, they were stainable by trypan blue without DOC-pretreatment. These findings suggest that exposure of macrophages to low ITCZ concentrations affects physiological condition of their cell membrane.
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