Secreted Aspartyl Proteinase(SAP) from Candida albicans: SAP also Functions as a Chemoattractant toward Neutrophils.:SAP also Functions as a Chemoattractant toward Neutrophils
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Secreted aspartyl proteinase from C. albicans is known as a pathogenic factor which degrades host tissues during the invasion process. Recently genes encoding SAP have been cloned, and their regulation mechanism is now being extensively investigated. During the process of investigating the various effects of SAP, we observed that SAP has a chemotactic activity toward neutrophils. The chemotactic activity of SAP was then examined by a modified Boyden chamber method using normal human peripheral leukocytes. SAP showed dose-dependent chemotactic activity for neutrophils with maximal activity at 500nM. Little chemotactic activity was observed for peripheral lymphocytes. Checkerboard analysis indicated that SAP is chemokinetic as well as chemotactic for neutrophils. SAP-injected guinea pig skin indicated significant infiltration of neutrophils. These results suggest that SAP, which theoretically acts as a host tissue-degrading enzyme, induces the migration of peripheral neutrophils to the C. albicans-infected site.
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