General View of Research on Defense Mechanism against Fungal Infection Using Experimental Dermatophytosis in Animals.
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Preparation and analysis of experimental dermatophytosis are both of great importance in order that mechanisms of dermatophytosis might be elucidated. Tagami et al. demonstrated hypersensitivity to constituents of dermatophytes in experimental dermatophytosis on hairy skin in guinea pig, and found that the dermatophytosis induces epidermal hyperproliferation which facilitates elimination of the fungi. Fujita et al. established a reproducible model of tinea pedis in guinea pig and indicated that inflammatory tissue reactions are mediated by delayed hypersensitivity. Although experimental dermatophytosis on the back of hairless guinea pig resembles human tinea corporis, this model remains to be improved. From the fact that experimental tinea pedis never heals spontaneously, we assumed that hair apparatus has an important role in spontaneous healing of experimental dermatophytosis on hairy skin. Therefore, we analyzed morphological alterations of hair apparatus evoked by dermatophyte infection in guinea pig using immunohistochemical methods. Most of the hair apparatus began to involute and retract synchronously on day 16 after inoculation of fungi. In hair bulb, DNA synthesizing cells decreased in number significantly in comparison with those on day 14. It is assumed that fungal infection induced hair apparatus to involute by affecting hair cycle. Alterations of cellular dynamics in hair apparatus is one of the important factors in mechanisms of spontaneous healing in experimental dermatophytosis on hairy skin in guinea pig.
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