Studies on an Antifungal Effect of Miconazole on Aspergillus fumigatus by BioCell-Tracer.
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概要
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A biocell-tracer developed by Matsuoka et al. determines the growth rate of single hyphae by monitoring their tips. This new apparatus was used to investigate the antifungal effect of miconazole (MCZ) on Aspergillus fumigatus.Eight-tenths (1/4 MIC) to 6.25μg/ml (2 MIC) of MCZ completely inhibited the hyphal growth within 60min at 30°C, and 12.5 (4 MIC) to 100μg/ml (32 MIC) of MCZ did so within 20min.Morphologically, when 0.8 to 1.6μg/ml of MCZ was added in an assay system hyphal tips became club-shaped, and when 3.2 to 25μg/ml of MCZ was added, hyphae formed short aberrant branches at the apical and subapical regions.Next, examination of the effect of human serum containing 1.1μg/ml, 3μg/ml or 7.6μg/ml of MCZ on A. fumigatus showed that the latter amount inhibited the hyphal growth.In conclusion, the biocell-tracer proved useful in this study on antifungal activity in filamentous fungi, and MCZ was suggested to be effective to treat systemic aspergillosis.
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