Detection of Aspergillus fumigatus Antigen in Sera and Urine of Rats with Experimental Recurrent Pulmonary Aspergillosis.

概要

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A new rat model of recurrent pulmonary aspergillosis using cyclophosphamide (CPM) for re-institution of immunosuppression was established. The recurrence induced by CPM was rapid and pulmonary lesions were uniform in all animals. It is therefore considered to be a good model for evaluation of the mechanisms of recurrence and methods of early diagnosis by antigen detection in sera and urine. Galactomannan antigen of aspergilli in sera was examined by PASTOREX Aspergillus, and a very low positive rate was observed instead of the of severe pulmonary infection confirmed by histopathological study. However, antigen in urine detected by immunoblotting showed a relatively high positive rate from the early stage of the recurrence. Based on these findings, it can be concluded that the recognition of antigenuria is useful for early diagnosis of Aspergillus infection.
日本医真菌学会の論文