Autopsy Case of Invasive Bronchopulmonary Aspergillosis Due to Aspergillus niger Forming Characteristic Conidial Heads in the Bronchi.
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概要
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We report a case of bronchopulmonary aspergillosis due to Aspergillus niger found at autopsy. The patient was a 64-year-old Japanese female who died of renal failure with recurrence of uterine leiomyosarcoma. The autopsy revealed typical invasive pulmonary aspergillosis in the lower lobe of the left lung. In the upper lobe of the same lung, numerous hyphae showed mural proliferation in the bronchi and terminal portions of the respiratory tree from which the hyphae invaded the surrounding pulmonary tissue. Although the tissue was not cultured, the conidial heads histologically disclosed in the air space were characteristic of Aspergillus niger. The histological pattern of the upper lobe lesion indicated colonization like non-invasive Aspergillus infection mixed with invasive bronchopulmonary aspergillosis. This case is very important in any discussion of the pathogenesis of semi-invasive bronchopulmonary aspergillosis.
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