Study on the Pathogenesis of Congenital Cutaneous Candidiasis.
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概要
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A series of experiments was carried out to elucidate the pathogenesis of congenital cutaneous candidiasis.<BR>1) In <I>in vitro</I> study on the proliferation rate and morphological changes of <I>C. albicans</I> cultivated in human amniotic fluid, human serum and Sabouraud's broth, respectively, the proliferation rate decreased significantly and the development of germ tubes and pseudohyphae increased in the former two more than in Sabouraud's broth.<BR>2) In experimental infection of fetal rat skin by intrauterine injection of a <I>C. albicans</I> suspension (10<SUP>6</SUP> cells/m<I>l</I>) only histological changes of adhesion and superficial invasion of <I>Candida</I> spores with germ tubes to the horny layer at 24 hrs were observed, suggesting the initial stage of infection. Forty-eight hours after injection there were clinical signs of scattered pustules and a unique histological finding of hyphal invasion through the epidermis to the dermis, where many polymorphonuclear leukocytes had infiltrated.<BR>3) The phagocytic activity and intracellular killing activity of fetal rat neutrophils against <I>C. albicans</I> cells were compared with those of adult rat neutrophils. The fetal rat neutrophils phagocytized at a rate of approximately 30% in one hour, and this was significantly lower than that by adult rat neutrophils. The two neutrophil groups showed almost the same intracellular killing activity: less than 1% within one hour.<BR>These results indicate that rat skin 48 hrs before parturition can easily be infected by <I>C. albicans</I>.
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