Pathology of Rare Deep-Seated Fungal Infections. With Special Attention Given to Trichosporonosis.:with Special Attention Given to Trichosporonosis

スポンサーリンク

概要

• 論文の詳細を見る

• This report describes pathological aspects of deep-seated trichosporonosis in cases reported in the literature (including our own) and in experimental animals, as follows: 1) Morphology of <I>Trichosporon</I> in the tissue sections was, although similar to <I>Candida</I>, characterized by the presence of both pseudohyphae and true hyphae of varying widths, and by various-shaped spores including arthroconidia. Immunostaining was useful in making a diagnosis of trichosporonosis in cases of unsuccessful culture of the causative organism. 2) In the literature up to 1991, 85 cases of deep-seated trichosporonosis had been reported. Sixty-seven cases were sepsis or disseminated infections and 55 had a hematological disorder, particularly leukemia, as an underlying disease. Many cases with unfavorable prognosis had necrotic or no cellular reactions in fungal lesions, while the improved cases showed, at least in part, suppurative and/or granulomatous inflammation, indicating that a patient's prognosis depends on the degree of impairment of the host defense mechanism. 3) Experimental trichosporonosis in mice confirmed the importance of host defense; intravenous inoculation of <I>Trichosporon beigelii</I> into leukopenic mice treated with anti-neoplastic drugs caused a generalized spread of fungal lesions without cellular reactions, while formation of suppurative granuloma with quick removal of the fungi was observed only in lungs in untreated control animals.

• 日本医真菌学会の論文

日本医真菌学会 | 論文

• (1→3)-β-D-グルカン測定の問題点と進歩
• 両側の肺空洞病変にアスペルギルス感染を合併し抗真菌薬, ミカファンギンとイトラコナゾールの併用療法が有効であった Wegener 肉芽腫症の一例
• Trichophyton tonsurans 臨床分離株に対する各種抗真菌薬の in vitro 抗真菌活性
• 爪白癬の治療について : 日本医真菌学会標準化委員会提案2007
• Candida 属菌種のアゾール系薬感受性試験における現行の日本医真菌学会法, およびその改変法とNCCLS M27-A2法との相関性に関する検討

もっと見る

スポンサーリンク