Latex Agglutination Test for the Detection of Candida Mannan Antigen in Sera of Patients with Visceral Candidiasis. (II).
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概要
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We examined the efficacy of the latex agglutination reagent prepared by Kyokuto Pharmaceutical Industrial Co., Ltd. (LA reagent) for serological diagnosis of visceral candidiasis. Candida mannan antigen was detected by LA reagent at a level of more than 3.9ng/ml in serum treated with protease. 228 sera were examined in this study (55 from cases with and 173 from cases without candidiasis). Mannan antigen was detected in 21 of 29 sera (72.4%) of patients with severe candidiasis, and 17 of 18 sera (94.4%) in the acute phase of severe candidiasis showed positive results. In contrast, the detection rate of mannan antigen was very low in cases of chronic or mild candidiasis (1 of 26 sera, 3.8%). Good corrlation between the change of titer of mannan antigen and severity of infection was shown in the experimental candidemia and gastric candidiasis of mice. The rate of correctly diagnosed cases using La reagent, CAND-TEC and Darabinitol in 65 sera was, respectively, 81.5%, 64.6% and 75.4%. These results indicate that LA reagent in useful for the diagnosis of visceral candidiasis.
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