Antidermatophytic Substance in the Epidermal Extract, its Characterization.
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概要
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Mycoses are caused by weak virulenced vectors and in this regard they prepare the good models to study the mechanisms of self-defense. We extracted candidacidal substance from guinea pig epidermis in 1981 and since then fractionation, purification and characterization of the substance have been carried out. Epidermal extract is consisted of many substances and the fractionation is very difficult to study. Recently we succeeded in the characterization, that is, the candidacidal activity is conducted by both basic epidermal protein and H1 histone, further characterization is now on the way.Oxidative, chelating, enzymatic and cationic systems engaging in the self-defense are also discussed.
- 日本医真菌学会の論文
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