Histopathological study of cardiac mycosis. Particularly on myocardial lesions of systemic mycosis.:Particularly on Myocardial Lesions of Systemic Mycosis

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The hearts with fungal infections in the myocardium obtained from 40 autopsy cases were studied histopathologically, focusing on the distribution and the extent of the lesions as well as their morphological characteristics.The lesions of Candida infections were seen in the wall of the left ventricle, especially in the two-thirds portion toward the endocardial side. In contrast, the lesions of Aspergillus were rarer, and tended to concentrate in a segment in each case.The lesions were classified into several types by their number, and by histological findings such as degeneration of myocardium or inflammatory cell infiltrate. Incidence was also studied. In Candida infections, lesions showing necrosis of myocardial cells with a few fungal elements were commonly seen. In cases with numerous lesions in the myocardium, the hyphae were scattered in multiple viscera. Concerning the relation to the number of leukocytes in peripheral blood before death, a prominent increase was frequently seen in lesions of the so-called abscess type. Lesions in Aspergillus infections were classified into two types: those with coagulation necrosis and with colliquation necrosis. In all cases, small arteries and veins were involved, and hyphae extended along the involved vascular lumen.There are differences in distribution and histological findings between species of fungi. In the lesions of Candida infections, the initial alterations were considered to be the micro-emboli of fungi in capillaries. In contrast, in Aspergillus infections, there was, in addition, presumed to be an extension of the lesions by the proliferation of hyphae along the involved vascular lumen.
日本医真菌学会の論文

Histopathological study of cardiac mycosis. Particularly on myocardial lesions of systemic mycosis.:Particularly on Myocardial Lesions of Systemic Mycosis

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日本医真菌学会 | 論文

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