Changes of lipid composition and enzyme activity in a dimorphic fungus, Candida albicans during yeast to mycelial transformation.
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概要
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Alterations in lipid composition of Candida albicans were examined during the yeast (Y) to mycelial (M) transformation. A comparative lipid analysis of plasma membranes from the two cell forms showed that the sterol content of M-form cells was approximately three times greater than that of Y-form cells. ESR spectra data revealed the less fluid physical state in M-form cells than in Y-form cells.The activity of chitin synthetase which is associated with plasma membranes was several times higher in the M-form than in the Y-form. These results suggest that modifications of membrane lipid composition play a role in the Y-M transformation of Candida albicans.It was further observed that Y-M transformation was completely inhibited when 50% inhibition of ergosterol biosynthesis was induced by an azole-antifungal agent. On the other hand, the same degree of inhibition of ergosterol biosynthesis showed no effect on the Y-form growth, suggesting that M-form cells were more susceptible to the ergosterol deficiency than Y-form cells.
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