Experimental candidiasis in carbon tetrachloride-induced liver injury.

概要

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In an attempt to evaluate effects of severe liver injury on susceptibility to Candida infection, we conducted experiments on experimental Candidiasis using mice with carbon tetrachloride-induced liver injury. In the group administered carbon tetrachloride, liver injury was characterized by necrosis of liver parenchyma predominantly distributed in the centrilobular area. With intravenous inoculation of Candida, these mice died earlier and final survival was 0%. In contrast, a 20% survival rate was seen in the group with Candida and without liver injury. Candidial lesions were extensive and disseminated, involving lung and heart in the group with liver injury, but predominantly localized to kidneys in the group without liver injury. This study demonstrated that susceptibility to Candida is enhanced in the presence of severe liver injury.In the group with liver injury, transferrin (TIBC) was significantly decreased as compared with the other group. Therefore, it is suggested that the decreased amount of TIBC may enhance the susceptibility to Candida infection; however, in the group with liver injury, administration of apotransferrin did not compensate the decreased TIBC, which was unable to reverse the carbon tetrachloride-induced Candida-enhancing activity. Thus, more studies are needed to fully understand the relationship between the roles of iron metabolism and increased susceptibility to Candida infection.
日本医真菌学会の論文