Protective effects of various BRMs against Candida albicans infection in mice.
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概要
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Antifungal effects of six BRMs (biological response modifiers : OK-432, LPS, lipid A, lentinan, levamisole and indomethacin) on murine candidiasis were studied. All BRMs tested showed protective effects against <I>Candida</I> infection. Among them, clinically useful BRMs, <I>i.e</I>., OK-432, lentinan and levamisole, also showed therapeutic effects against the infection. On the basis of survival curves of each BRM-treated mouse, it was found that the BRMs were classified into two groups. The first group exhibited a higher survival rate in the early stage of <I>Candida</I> infection, and the second group exhibited the effect in the late stage of <I>Candida</I> infection. Lipid A belonged to the former group, while lentinan and levamisole were classified in the latter group. OK-432, LPS and indomethacin were considered to be an intermediate group. As a possible effector against <I>Candida</I> infection, the important role of peritoneal macrophages (PECs) was suggested, because PECs from lentinan or levamisole treated mice showed a strong inhibitory activity against germ tube formation of C. <I>albicans</I>. Potential clinical usefulness of some anticancer BRMs as immunotherapeutic agents against opportunistic fungal infections was indicated.
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