Alterations in lipid composition of plasma membranes from dimorphic fungus, Candida albicans, during the yeast to hyphal transformation.
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Alterations in lipid composition of purified plasma membranes from Candida albicans were examined during the yeast to hyphal transformation. The levels of both phosphatidylcholine (PC) and phosphatidylethanolamine (PE) increased by 5 and 10%, respectively three hours after transfer, while phosphatidylserine (PS) and phosphatidic acid (PA) decreased by 10% respectively. Marked changes were also observed to occur in the fatty acid composition of phospholipids three hours after transfer. There was a great increase in linoleic acid with a compensatory decrease in oleic acid in PC, PE and PS, suggesting enhanced desaturation activity. Such replacement of monoene by diene led to the high unsaturation index associated with the yeast to hyphal transformation. The fatty acid composition of phosphatidylinositol showed a striking decrease in palmitoleic acid with a concomitant increase in palmitic acid. These results suggest that modification of plasma membrane lipid composition might be associated with the morphological conversion from yeast to hyphae in C. albicans.
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