Clinical evaluation of Ketoconazole in mycosis in the field of internal medicine.
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概要
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Ketoconazole was given to 12 mycosis patients: 2 suffered from candidemia, 4 from candiduria, 3 were thought to have mycotic pneumonia or pulmonary mycosis, 1 had aspergilloma, 1 a subcutaneous abscess by Candida, and 1 intracerebral cryptococcosis. The results of the clinical trials were markedly effective in 1 patient, effective in 5, slightly effective in 5 and ineffective in 1 patient. Ketoconazole was therefore considered effective in the treatment of 6 patients out of 12. Detected fungi were Candida sp. in 9 cases and Aspergillus sp. in 1 case. The causative agents disappeared in 7 cases, decreased in 1 case, were replaced from Candida albicans to Aerobacter cloacae in 1 and were unknown in 1 case. No particular side effects were observed except for an increase in GOT, GPT and Al-p in 1 case. Ketoconazole, in its formulation for oral use, is thought to be an effective antimycotic drug for deep mycosis at this time when there are only a few antimycotic drugs.
- 日本医真菌学会の論文
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