Fine architecture of cell walls in pathogenic fungi.

概要

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Recent information about chemical and ultrastructural architecture of dermatophyte cell walls was summarized. Cell walls of dermatophytes consist of two layers; the inner electron lucent, thick (0.1 to 0.5μm in thickness) and the outer electron dense, thin (20 to 500nm in thickness) layers. The inner layer is composed of microfibrils and an amorphous matrix. The microfibrils are made from the chitinous "bricks" enveloped with glucan, mannan and peptides. The cement-like amorphous matrix is composed of glucan, mannan, galactomannan and peptides. The outer layer, which is biochemically composed of protein, is observed as rodlet fascicles interwoven into a basket-weave-like structure. In the present study, the length of rodlets showed no differences amongst hyphae, micro- and macrocondidia of Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis and Microsporum gypseum, and no rodlet sturctures were seen on the cell wall of Epidermophyton floccosum. The orientation of rodlets was approximately perpendicular to the long axis of the hyphae and circular at the base of conidium in young cells. The outer layer of the dermatophyte cell walls is similar to some bacterial cell walls in chemistry and ultrastructure, although the inner layer is apparently different from them.
日本医真菌学会の論文