:III. Their Effects on Complement and Peripheral Leukocytes
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概要
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One of the glycoprotein toxins (Fr II-2) isolated from a Candida albicans strain is descrived with complement-activation capacity both in vivo and in vitro. Fr II-2 was not found to convert C3 into its faster electrophoretic form when incubated in normal human serum. EDTA and EGTA completely inhibited the complement-activating activity of the toxin, suggesting that this complement activation would be entirely accomplished via the classical pathway. The toxin decreased the number of peripheral lymphocytes and increased that of neutrophiles when intravenously injected into rabbits. The same effects on peripheral leukocytes were also attained by intravenous injection of cellular mannan, formol-killed cells or living cells of C. albicans. It seems, therefore, that the glycoprotein toxins would play an important part in the course of C. albicans infection.
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